Xue Zhi Zhao Selected Research

Integrases

11/2021	HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants.
1/2021	Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.
1/2021	Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs.
1/2018	Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants.
1/2016	Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.
1/2016	6,7-Dihydroxyisoindolin-1-one and 7,8-Dihydroxy-3,4-Dihydroisoquinolin- 1(2H)-one Based HIV-1 Integrase Inhibitors.
2/2014	Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Xue Zhi Zhao Research Topics

Disease

8	Acquired Immunodeficiency Syndrome (AIDS) 11/2021 - 06/2009
7	Infections 01/2021 - 02/2014
2	Neoplasms (Cancer) 11/2019 - 01/2017
2	HIV Infections (HIV Infection) 01/2016 - 11/2011

Drug/Important Bio-Agent (IBA)

7	IntegrasesIBA 11/2021 - 02/2014
7	Human immunodeficiency virus 1 p31 integrase proteinIBA 07/2018 - 06/2009
2	Anti-Retroviral Agents (Antiretroviral Agents)IBA 01/2016 - 02/2014
2	EnzymesIBA 01/2016 - 06/2009
2	Raltegravir Potassium FDA Link 12/2012 - 11/2011
1	imidazole mustard (BIC)IBA 01/2020
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2017
1	Deubiquitinating EnzymesIBA 01/2017
1	PiperidonesIBA 01/2017
1	UbiquitinIBA 01/2017
1	RA190IBA 01/2017
1	HIV Integrase InhibitorsIBA 07/2014
1	elvitegravirIBA 12/2012

Therapy/Procedure

3	Therapeutics 11/2019 - 01/2016